The regulation includes several annexes, of which Part-FCL (Flight Crew Licensing, Annex I) and Part-MED (Medical Certification, Annex IV) are the most important ones for pilots.<ref>The other annexes are concerned with the cabin crew in Part-CC (Annex V), the aircrew requirements for the National Aviation Authorities - e.g. the UK Civil Aviation Authority (CAA) for the United Kingdom or the German Luftfahrtbundesamt (LBA) for Germany - in Part-ARA (Annex VI), the aircrew requirements for organizations - such as aeromedical centres and training organizations - in Part-ORA (Annex VII) and requirements for Declared Training Organizations in Part-DTO (Annex VIII).

</ref> In order to act as a pilot-in-command of an "EASA aircraft" as specified in the Regulation, it is a regulated requirement to hold a pilot license according to Part-FCL, in principle. However, due to the burdensome requirements for organizations - such as gliding clubs - for training towards such a pilot licence (non-commercial), Part-DTO (Annex VIII) was introduced by Commission Regulation (EU) 2018/1119 of 31 July 2018 to promote more flexibility within General Aviation.