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extra equipment
# Keep your bicycle lubricated, especially the transmission. Set your shifters correctly so that the chain does not squeak or rub on things while you ride.
# Have a professional bike fit (it's money well spent) to make sure your sitting position is ergonomic on your bicycle. This is a higher requirement than being "comfortable" as there is quite a wide range of positions that you will feel comfortable in if you only try it for five minutes. Sitting in an ergonomic position will help you to save effort while cycling for long distances, and more importantly, to minimise the likelihood of injury.
=== Extra equipment that helps ===
The author has found over the past few years that the following will help to make the trip easier:
# A sat nav device (either for cycling, or your google map on your mobile phone provided you can secure it to the handlebar and the battery lasts) for the first couple of trips to help you to get to know the way.
# Clipless pedals makes cycling easier. However, before taking them onto the highway do make sure you know how to use these. Falling over on a road where the speed limit is 60mph is not fun. Besides, if you decide to use the "road" style of pedals and cleats instead of the "MTB" style, you will need to bring a pair of walking shoes with you. Flying (and driving trucks etc.) with cleats under your shoes is very hazardous, don't try.
# A water bladder eliminates the need of reaching for the water bottle every time you wish to drink water.
# A bright torch if you plan to return after sunset.
# A puncture repair kit (and knowing how to use them), which usually includes either patches or sealant or a spare tyre, and some means of inflation, either a pump or a can of compressed carbon dioxide.
# A pair of gloves just in case you need to work on the chain.